Chemical Structure : SJ-733
CAS No.:
1424799-20-1
SJ-733
((+)-SJ733;SJ000557733;SJ-557733)
Catalog No.: PC-61904Not For Human Use, Lab Use Only.
SJ-733 (SJ000557733.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite; displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60 nM; kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailability
Parasite Infection
Phase 1 Clinical
Physicochemical Properties
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M.Wt
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468.412
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Formula
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C24H16F4N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3S,4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(3-pyridinyl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydro-4-isoquinolinecarboxamide
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References
1. Jiménez-Díaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.
2. Crawford ED, et al. PLoS One. 2017 May 22;12(5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20;11(12):e0168362.
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