Chemical Structure : SN-401
CAS No.: 82749-70-0
Catalog No.: PC-72941Not For Human Use, Lab Use Only.
SN-401 (DCPIB) is a SWELL1 channel inhibitor that bind the SWELL1-LRRC8 channel complexes (IC50=3.9 uM).
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50 mg | $428 | In stock | |
100 mg | $728 | In stock | |
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SN-401 (DCPIB) is a SWELL1 channel inhibitor that bind the SWELL1-LRRC8 channel complexes (IC50=3.9 uM).
SN-401 increases adipocyte SWELL1 protein expression, and SWELL1-dependent insulin signaling.
SN-401 increases SWELL1 and improves systemic glucose homeostasis in murine T2D models by enhancing insulin sensitivity and secretion.
SN-401 improves systemic insulin sensitivity, tissue glucose uptake, and nonalcoholic fatty liver disease in murine T2D models.
SN-401 inhibits ICl,SWELL but promote SWELL1-dependent signaling at sub-micromolar concentrations (0.1-1 uM).
SN-401 prevents reductions in SWELL1 protein and rescues SWELL1-dependent islet insulin secretion under glucolipotoxic conditions.
SN-401 congeners improve glycemic control in murine T2D models
M.Wt | 427.362 | |
Formula | C22H28Cl2O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4-((6,7-dichloro-2-cyclopentyl-1-oxo-2-pentyl-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid |
1. David M Kern, et al. Elife. 2019 Feb 18;8:e42636.
2. Gunasekar SK, et al. Nat Commun. 2022 Feb 10;13(1):784.
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