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SR31527

Chemical Structure : SR31527

CAS No.: 311814-78-5

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SR31527 (SR 31527;SR-31527)

Catalog No.: PC-63479Not For Human Use, Lab Use Only.

SR31527 is an allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SR31527 is an allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM.
    SR31527 prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.

    Physicochemical Properties

    M.Wt 319.807
    Formula C15H14ClN3OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-amino-3-(4-methoxyphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium chloride

    References

    1. Zhang W, et al. Biochem J. 2016 Apr 15;473(8):1027-35.

    2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21;116:33-41.

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