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Chemical Structure : Senexin-A
CAS No.: 1366002-50-7
Catalog No.: PC-44628Not For Human Use, Lab Use Only.
Senexin-A is a selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19, inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively.
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| 10 mg | $258 | In stock | |
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Senexin-A is a selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19, inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively.
Senexin-A inhibits only p21-induced transcription but not other biological effects of p21, inhibits β-catenin-dependent transcription in HCT116 colon carcinoma cells.
Senexin-A suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts.
Senexin-A reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with doxorubicin.
| M.Wt | 274.32 | |
| Formula | C17H14N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥100 mg/mL |
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| Chemical Name/SMILES |
6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]- |
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1. Porter DC, et al. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804.
2. McDermott MS, et al. Oncotarget. 2017 Feb 21;8(8):12558-12575.
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