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Chemical Structure : TG-101348
CAS No.: 936091-26-8
Catalog No.: PC-42569Not For Human Use, Lab Use Only.
TG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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TG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F.
TG-101348 also inhibits FLT3 (IC50=15 nM) and RET (IC50=48 nM) kinases, weakly inhibits JAK3 (IC50=168 nM), >35-fold selectivity over JAK1/3 and Tyk2.
TG-101348 shows therapeutic efficacy in a murine model of myeloproliferative disease induced by the JAK2V617F mutation.
TG-101348 also potently inhibits BRD4 with Kd of 168 nM.
| M.Wt | 524.6782 | |
| Formula | C27H36N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]- |
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1. Pardanani A, et al. Leukemia. 2007 Aug;21(8):1658-68.
2. Ciceri P, et al. Nat Chem Biol. 2014 Apr;10(4):305-12.
3. Wernig G, et al. Cancer Cell. 2008 Apr;13(4):311-20.
4. Geron I, et al. Cancer Cell. 2008 Apr;13(4):321-30.
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