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Chemical Structure : TLR3-dsRNA complex inhibitor
Catalog No.: PC-20180Not For Human Use, Lab Use Only.
TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM.
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TLR3/dsRNA Complex Inhibitor (CU-CPT4a, TLR3i) is a specific small molecule inhibitor targeting the dsRNA binding region of TLR3 with Ki of 2.96 uM, blocks Poly (I:C)-induced TLR3 activation with IC50 of 3.44 uM.
TLR3/dsRNA Complex Inhibitor (TLR3i) inhibits TLR3 signaling without affecting other TLRs (TLR1/2, TLR2/6, TLR3, TLR4, and TLR7).
TLR3/dsRNA Complex Inhibitor disrupts the TLR3/dsRNA association by directly targeting the RNA-binding site on TLR3.
TLR3/dsRNA Complex Inhibitor also inhibits the downstream signaling transduction mediated by the formation of the TLR3/dsRNA complex. TLR3/dsRNA Complex Inhibitor abolishes the TNF-α and IL-1β production activated by 15 µg/ml Poly (I:C) in the RAW 264.7 cells with IC90 of 27 uM.
| M.Wt | 377.81 | |
| Formula | C18H13ClFNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheng K, et al. J Am Chem Soc. 2011 Mar 23;133(11):3764-7.
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