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Chemical Structure : TLR789 inhibitor 7f
Catalog No.: PC-72051Not For Human Use, Lab Use Only.
TLR789 inhibitor 7f is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4.
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TLR789 inhibitor 7f (BMS-615) is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4.
TLR789 inhibitor 7f inhibits IL-6 prodcution via TLR7/8/9 inhibitory response in human whole blood (mWB) assays with IC50 of 5.7/5.1/320 nM, respectively.
TLR789 inhibitor 7f effectively blocks cytokine production elicited by treatment with agonists of TLR7 (gardiquimod) or TLR9 (ODN1585) in mouse pharmacodynamic (PD) models, dose-dependently decreases agonist-induced IL-6 production with plasma EC50 of 2.4 nM (TLR7) or 25 nM (TLR9).
| M.Wt | 435.612 | |
| Formula | C27H37N3O2 | |
| Appearance | Solid | |
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1. Christopher P Mussari, et al. ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758.
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