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Chemical Structure : Tegatrabetan
CAS No.: 1227637-23-1
Catalog No.: PC-61288Not For Human Use, Lab Use Only.
Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.
BC-2059 reduces transcriptional activity of TCF4 and expression of its target genes, cyclin D1, c-MYC and survivin.
BC-2059 treatment dose-dependently induced apoptosis of cultured and primary AML BPCs.
BC-2059 significantly improves the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs.
| M.Wt | 588.74 | |
| Formula | C28H36N4O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel- |
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1. Fiskus W, et al. Leukemia. 2015 Jun;29(6):1267-78.
2. Savvidou I, et al. Mol Cancer Ther. 2017 Sep;16(9):1765-1778.
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