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Tegatrabetan

Chemical Structure : Tegatrabetan

CAS No.: 1227637-23-1

Tegatrabetan (BC-2059;BC2059;Tegavivint)

Catalog No.: PC-61288Not For Human Use, Lab Use Only.

Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.
BC-2059 reduces transcriptional activity of TCF4 and expression of its target genes, cyclin D1, c-MYC and survivin.
BC-2059 treatment dose-dependently induced apoptosis of cultured and primary AML BPCs.
BC-2059 significantly improves the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs.

Physicochemical Properties

M.Wt 588.74
Formula C28H36N4O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-

References

1. Fiskus W, et al. Leukemia. 2015 Jun;29(6):1267-78.

2. Savvidou I, et al. Mol Cancer Ther. 2017 Sep;16(9):1765-1778.

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