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UBCS039

Chemical Structure : UBCS039

CAS No.: 358721-70-7

UBCS039 (UBCS-039, UBCS 039)

Catalog No.: PC-35856Not For Human Use, Lab Use Only.

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.

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Biological Activity

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.
UBCS039 shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities.
UBCS039 induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.

Physicochemical Properties

M.Wt 247.301
Formula C16H13N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

References

1. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011.

2. Iachettini S, et al. Cell Death Dis. 2018 Sep 24;9(10):996.

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