UC1728 | sEH inhibitor | Probechem Biochemicals

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Chemical Structure : UC1728

CAS No.: 948304-40-3

UC1728 (t-TUCB, UC-1728)

Catalog No.: PC-35971Not For Human Use, Lab Use Only.

UC1728 (t-TUCB, UC-1728) is a potent and orally available inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 2.0 nM (rabbit liver sEH).

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UC1728 (t-TUCB, UC-1728) is a potent and orally available inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 2.0 nM (rabbit liver sEH).
UC1728 reduces ocular inflammation in a rabbit LPS-induced model of uveitis.

Physicochemical Properties

M.Wt	438.403
Formula	C21H21F3N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-4-{4-[3-(4-Trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy}-benzoic acid

References

1. McLellan GJ, et al. J Ocul Biol. 2016 Jan;4(1). doi: 10.13188/2334-2838.1000024.

2. Hwang SH, et al. J Med Chem. 2007 Aug 9;50(16):3825-40.

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UC1728 (t-TUCB, UC-1728)

Biological Activity

Physicochemical Properties

References

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