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Chemical Structure : USP7 inhibitor AD-04
Catalog No.: PC-60003Not For Human Use, Lab Use Only.
USP7 inhibitor AD-04 ((R)-USP-IN-4) is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays, SPR Kd of 2 nM.
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USP7 inhibitor AD-04 ((R)-USP-IN-4) is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays, SPR Kd of 2 nM.
AD-04 also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5 nM).
AD-04 displays high selectivuty (>38-fold) against other DUBs, proteases and kinases.
AD-04 demonstrates highly potent target engagement in cells (EC50=49 nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells.
| M.Wt | 514.63 | |
| Formula | C29H34N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gavory G, et al. Nat Chem Biol. 2018 Feb;14(2):118-125.
2. Anamarija Jurisic, et al. Clin Transl Med. 2024 Apr;14(4):e1648.
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