Chemical Structure : Vatalanib free base
CAS No.: 212141-54-3
Catalog No.: PC-42448Not For Human Use, Lab Use Only.
A potent, orally available class III receptor tyrosine kinases inhibitor with IC50 of <1 uM for VEGFR, Flt-1, KDR and PDGFRβ.
Packing | Price | Stock | Quantity |
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10 mg | $56 | In stock | |
50 mg | $144 | In stock |
Bulk size, bulk discount!
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A potent, orally available class III receptor tyrosine kinases inhibitor with IC50 of <1 uM for VEGFR, Flt-1, KDR and PDGFRβ; shows no activity against EGFR, FGFR-1, c-Met, and Tie-2, or c-Src, c-Abl, and PKC-α; blocks the VEGF-induced receptor autophosphorylation in CHO cells ectopically expressing the KDR receptor with IC50 of 34 nM; inhibits EGF and PDGF-induced angiogenesis in a growth factor implant model (25-100 mg/kg).
Ovarian Cancer
Phase 1 Discontinued
M.Wt | 346.8129 | |
Formula | C20H15ClN4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)- |
1. Bold G, et al. J Med Chem. 2000 Jun 15;43(12):2310-23.
2. Wood JM, et al. Cancer Res. 2000 Apr 15;60(8):2178-89.
3. Drevs J, et al. Cancer Res. 2000 Sep 1;60(17):4819-24.
4. Hess C, et al. Br J Cancer. 2001 Dec 14;85(12):2010-6.
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