WIN-18446 |CAS:1477-57-2 Probechem Biochemicals

Chemical Structure : WIN-18446

CAS No.: 1477-57-2

WIN-18446 (WIN18446;WIN 18446)

Catalog No.: PC-60168Not For Human Use, Lab Use Only.

WIN-18446 is a potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.

Packing	Price	Stock
50 mg	$78	In stock
100 mg	$128	In stock
200 mg	$198	In stock
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Biological Activity

WIN-18446 is a potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.
WIN-18446 potently inhibits spermatogenesis and causes infertility in vivo by inhibiting retinoic acid synthesis.

Physicochemical Properties

M.Wt	366.11
Formula	C12H20Cl4N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)

References

1. Amory JK, et al. J Androl. 2011 Jan-Feb;32(1):111-9.

2. Paik J, et al. J Biol Chem. 2014 May 23;289(21):15104-17.

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WIN-18446 (WIN18446;WIN 18446)

Biological Activity

Physicochemical Properties

References

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