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Chemical Structure : ZCZ011
CAS No.: 1998197-39-9
Catalog No.: PC-73251Not For Human Use, Lab Use Only.
ZCZ011 is a positive allosteric modulator of CB1 receptor, increases specific binding of CB1 receptor orthosteric agonist [3H]CP55,940 to mouse brain membranes with pEC50 of 6.9.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 25 mg | $548 | In stock | |
| 100 mg | $1280 | In stock | |
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ZCZ011 is a positive allosteric modulator of CB1 receptor, increases specific binding of CB1 receptor orthosteric agonist [3H]CP55,940 to mouse brain membranes with pEC50 of 6.9.
ZCZ011 also produced a significant and concentration-dependent increase in the specific binding of the CB1 receptor orthosteric agonist [3H]WIN55212 to mouse brain membranes with pEC50 of 6.3.
ZCZ011 significantly enhanced AEA-stimulated [35S]GTPγS binding at 100 nM.
ZCZ011 potentiated β-arrestin recruitment, and ERK phosphorylation assays.
ZCZ011 is brain penetrant, exhibits antinociceptive effects in neuropathic and inflammatory pain models with no associated cannabimimetic effects.
| M.Wt | 362.44 | |
| Formula | C21H18N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl-1H-indole |
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1. Ignatowska-Jankowska BM, et al. Neuropsychopharmacology. 2015 Dec;40(13):2948-59.
2. Mitjavila J, et al. Pharmacol Res. 2018 Mar;129:475-481.
3. Saleh N, et al. Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2580-2585.
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