| Cat. No. |
Product Name |
Information |
| PC-21047 |
YHJ1039
FLT3 inhibitor
|
YHJ1039 is a broad-spectrum kinase inhibitor, possesses excellent potencies against FLT3 mutants (FLT3 D835Y, IC50=0.41 nM) as well as FAK (IC50=7 nM). |
| PC-72759 |
CCT245718
Aurora A/FLT3 inhibitor
|
CCT245718 is a potent, dual Aurora A/FLT3 inhibitor with Kd of 39 nM (FLT3 D835Y) and 170 nM (FLT3 ITD), IC50 of 15 nM (Aurora A). |
| PC-72543 |
Marbotinib
FLT3 inhibitor
|
Marbotinib (FLT3i-3, Methanone 16) is a highly potent, specific, next-generation FLT3 inhibitor. |
| PC-72044 |
NCGC1481
IRAK1/4 inhibitor, FLT3 inhibitor
|
NCGC1481 (NCGC 1481) is a novel potent, type I kinase inhibitor against IRAK1/4 and FLT3, with IC50 of 22.6/0.8 nM and <0.5 nM respectively. |
| PC-35272 |
AAE871
FLT3 inhibitor
|
AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity. |
| PC-35271 |
ATH686
FLT3 inhibitor
|
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase. |
| PC-35270 |
AUZ454
FLT3 inhibitor
|
AUZ454 (AUZ-454, K03861) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase. |
| PC-35238 |
MZH29
FLT3 inhibitor
|
MZH29 is a novel potent, selective, orally active type II FLT3 inhibitor with IC50 of 9 nM and 7 nM against FLT3-WT and FLT3-ITD, respectively. |
| PC-63548 |
LDD1937
FLT3 inhibitor
|
LDD1937 is a selective, potent FLT3 inhibitor with IC50 of 3 nM, displays >170-fold selectivity over JAK2/3, c-MET, IRAK-4. |
| PC-63517 |
EC-70124
Multikinase inhibitor
|
EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM). |
| PC-43403 |
Crenolanib
FLT3 inhibitor
|
Crenolanib (CP-868596) is a potent, selective PDGFR/Flt-3 inhibitor with Ki of 3.2, 2.1 and 0.74 nM for wild-type PDGFRα, PDGFRβ and FLT3, respectively. |
| PC-43312 |
Quizartinib
FLT3 inhibitor
|
Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively. |
