| Cat. No. |
Product Name |
Information |
| PC-63198 |
BDT001
FLT3 inhibitor
|
BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM. |
| PC-42981 |
G-749
FLT3 inhibitor
|
Denfivontinib (G-749) is a potent, broad-spetrum FLT-3 inhibitor with IC50 of 0.4 and 0.6 nM against wt FLT-3 and FLT3-D835Y mutant, respectively. |
| PC-63101 |
JH-IX-179
FLT3 inhibitor
|
JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively. |
| PC-62529 |
HSD1169
FLT3 inhibitor
|
HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM). |
| PC-60368 |
FLT3-IN-5e
FLT3 inhibitor
|
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM. |
| PC-42447 |
Tandutinib
FLT3/Kit/PDGFR inhibitor
|
Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively. |
| PC-43033 |
Gilteritinib
FLT3/AXL inhibitor
|
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively). |
| PC-42536 |
KW-2449
Multikinase inhibitor
|
KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively. |
| PC-25422 |
PLM-101 hydrochloride
FLT3/RET inhibitor
|
PLM-101 hydrochloride is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively. |
| PC-25421 |
PLM-101
FLT3/RET inhibitor
|
PLM-101 is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively.
PLM-101 inhibits the proliferation of Ba/F3 cells expressing FLT3-ITD-mutant kinases at the nanomolar (nM) concentration levels. |
| PC-24959 |
CCT241736
FLT3/Aurora kinase inhibitor
|
CCT241736 (Mobinitinib) is a potent, orally bioavailable dual FLT3/Aurora kinase inhibitor with binding Kd of 7.5/48/6.2/38/14 nM for Aurora-A/Aurora-B/FLT3 WT/FLT3-ITD/FLT3(D835Y) respectively. |
| PC-24406 |
Clifutinib besylate
FLT3-ITD inhibitor
|
Clifutinib besylate (HEC73543) is potent, selective FLT3-ITD (internal tandem duplication mutations of FLT3) inhibitor with biochemical IC50 of 15.1 nM, exhibits significant antiproliferative activity against Ba/F3-FLT3-ITD cells with IC50 of 0.9 nM. |
