| Cat. No. |
Product Name |
Information |
| PC-24405 |
Clifutinib
FLT3-ITD inhibitor
|
Clifutinib (HEC73543) is potent, selective FLT3-ITD (internal tandem duplication mutations of FLT3) inhibitor with biochemical IC50 of 15.1 nM, exhibits significant antiproliferative activity against Ba/F3-FLT3-ITD cells with IC50 of 0.9 nM. |
| PC-24328 |
CHMFL-FLT3-122
FLT3 inhibitor
|
CHMFL-FLT3-122 (HYML-122, TR122) is a potent, selective and orally active FLT3 kinase with IC50 of 40 nM, shows >10-fold selectivity over BTK (IC50=421 nM) and c-KIT (IC50=559 nM) kinases, also selectively targets RIPK2 kinase with IC50 of 14 nM. |
| PC-24149 |
Lomonitinib
FLT3/IRAK4 inhibitor
|
Lomonitinib (ZE46-0134) is a highly potent and selective pan-FLT3/IRAK4 inhibitor, targets clinically relevant FLT3 mutations (ITD, TKD) including the gatekeeper mutation, as well as IRAK4, a putative escape pathway for FLT3-driven acute myeloid leukemia (AML). |
| PC-24145 |
PHI-101
FLT3 inhibitor
|
Lasmotinib (PHI-101) is a potent, selectivean orally bioavailable next-generation FLT3 inhibitor, overcomes secondary mutations. |
| PC-23460 |
SKLB1028
EGFR/FLT3/Abl inhibitor
|
SKLB1028 (Ruserontinib) is a potent, oral multikinase inhibitor of EGFR, FLT3 and Abl with IC50 of 55 nM (FLT3), potently inhibits the wild-type and L858R-mutant EGFR with IC50 values of 31 nM and 4 nM, respectively. |
| PC-22539 |
HSN748
FLT3 inhibitor
|
HSN748 is potent, selective, type II inhibitor of FLT3 (Kd=0.15 nM) and FLT3 mutants (FLT3 D835Y, KD=1.4 nM), shows potently effective against drug-resistant secondary mutations of FLT3. |
| PC-21565 |
TSN084
Multikinase inhibitor
|
TSN084 (TSN 084) is a unique small molecule multi-kinase inhibitor of drug-resistant mutations of c-Met, Trks, and Flt3, also inhibits other oncotargets including Axl, DDRs, and CDK8/19. |
| PC-21047 |
YHJ1039
FLT3 inhibitor
|
YHJ1039 is a broad-spectrum kinase inhibitor, possesses excellent potencies against FLT3 mutants (FLT3 D835Y, IC50=0.41 nM) as well as FAK (IC50=7 nM). |
| PC-20211 |
PCW-A1001
FLT3 D835Y inhibitor
|
PCW-A1001 is a potent, selective inhibitor of FLT-3 (D835Y) mutant with IC50 of 764 nM, weakly inhibits WT FLT-3 with IC50 of 2.54 uM. |
| PC-20025 |
HM43239
FLT3 inhibitor
|
HM43239 (Tuspetinib, HM-43239) is a highly potent, selective FLT3 kinase inhibitor with IC50 of 1.1 nM, 1.8 nM and 1.0 nM aginst FLT3 WT, FLT3 ITD and FLT3 D835Y kinases, respectively. |
| PC-47032 |
MBP-11901
Multikinase inhibitor
|
MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM). |
| PC-38742 |
FLT3 inhibitor 7c
FLT3 inhibitor
|
FLT3 inhibitor 7c is a novel potent FLT3 inhibitor with IC50 of 207.2, 215.3 and 32.5 nM for FLT3 (WT), FLT3 (D835Y) and FLT3 (ITD), respectively. |
