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Cat. No. Product Name Information
PC-21571

TY-2136

ROS1/TRK/ALK inhibitor

TY-2136 is a next generation ROS1/TRK/ALK inhibitor with IC50 of 1.6 nM and 460.1 nM for ROS1 G2032R and TRKA G595R, respectively, inhibits ROS1/TRK/ALK mutations and overcomes drug resistance due to acquired solvent-front mutations.
PC-20952

Unecritinib

ALK/ROS1 inhibitor

Unecritinib (TQ-B3101) is a novel kinase inhibitor targeting receptor tyrosine kinases including ALK, ROS1 and MET, inhibits AKT phosphorylation and downstream signaling molecules ERK1/2, has IC50 of 142.7 nM for wildtype ROS1.
PC-49635

NVL-520

ROS1 inhibitor

Zidesamtinib (NVL-520, NVL520) is a potent, selective, TRK-sparing, and brain-penetrant inhibitor of ROS1 fusions and secondary resistance mutations with IC50 of 0.5-3.5 nM, and 12 nM for ROS1 WT.
PC-73061

Taletrectinib

ROS1/NTRK inhibitor

DS-6051b (Taletrectinib, DS 6051b) is a new-generation selective ROS1/NTRK inhibitor, potently inhibits recombinant ROS1, NTRK1, and NTRK3 in sub-nanomolar concentration in ATP-competitive manner (IC50=1-10 nM).
PC-35262

WY-135

ALK/ROS1 inhibitor

WY-135 (WY135) is a potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
PC-42919

Lorlatinib

ALK/ROS1 inhibitor

Lorlatinib (PF-06463922) is a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with IC50 of 0.07/0.025 nM respectively.
PC-73163

ROS1 fusion inhibitor I

ROS1 fusion inhibitor

ROS1 fusion inhibitor I is a carcinogenic fused kinase (Ros1 fusion kinase) inhibitor.

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