| Cat. No. |
Product Name |
Information |
| PC-27496 |
WX-02-43
WX-02-23 negative control
|
WX-02-43 is a weak covalent inhibitor of SF3B1 and (1S,3R) enantiomer negative control probe of WX-02-23, cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. |
| PC-26407 |
BIO-6553
HTT-splicing modulator
|
BIO-6553 is a potent, CNS-penetrant, selective, and orally bioavailable Huntington gene (HTT)-splicing modulator with HTT HTRF IC50 of 54 nM. |
| PC-23569 |
PSF inhibitor No. C-30
PSF inhibitor
|
PSF inhibitor No. 10-3 is a small molecule inhibitor of RNA-binding protein PTB-associated splicing factor (PSF), effectively inhibits PSF-lncRNA interaction and inhibits PSF target gene expression at the mRNA level. |
| PC-23056 |
Votoplam hydrochloride
HTT splicing modulator
|
Votoplam (PTC518) hydrochloride is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein. |
| PC-21151 |
HTT splicing modulator 27
HTT splicing modulator
|
HTT splicing modulator 27 is a potent, orally bioavailable, and brain-penetrant small-molecule HTT pre-mRNA splicing modulator with mHTT protein EC50 of 66 nM. |
| PC-21086 |
Pladienolide B
SF3B1 inhibitor
|
Pladienolide B is a potent inhibitor targeting the SF3B1 subunit of the spliceosome, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. |
| PC-21062 |
SMNDC1 inhibitor 28
SMNDC1 inhibitor
|
SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN. |
| PC-73161 |
Thailanstatin D
ADC cytotoxin
|
Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities. |
