Spliceosome (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-21151	HTT splicing modulator 27 HTT splicing modulator	HTT splicing modulator 27 is a potent, orally bioavailable, and brain-penetrant small-molecule HTT pre-mRNA splicing modulator with mHTT protein EC50 of 66 nM.
PC-21086	Pladienolide B SF3B1 inhibitor	Pladienolide B is a potent inhibitor targeting the SF3B1 subunit of the spliceosome, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing.
PC-21062	SMNDC1 inhibitor 28 SMNDC1 inhibitor	SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN.
PC-73161	Thailanstatin D ADC cytotoxin	Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities.

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