| Cat. No. |
Product Name |
Information |
| PC-62422 |
Sudemycin K
Splicing inhibitor
|
Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM. |
| PC-62421 |
Sudemycin E
Splicing inhibitor
|
Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing. |
| PC-62420 |
FR901464
Spliceosome inhibitor
|
FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases. |
| PC-62419 |
Meayamycin
Spliceosome inhibitor
|
Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells. |
| PC-42098 |
Madrasin
Spliceosome inhibitor
|
A small molecule inhibitor of pre-mRNA splicing that interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex. |
| PC-23056 |
Votoplam hydrochloride
HTT splicing modulator
|
Votoplam (PTC518) hydrochloride is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein. |
| PC-23055 |
Votoplam
HTT splicing modulator
|
Votoplam (PTC518) is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein. |
| PC-21151 |
HTT splicing modulator 27
HTT splicing modulator
|
HTT splicing modulator 27 is a potent, orally bioavailable, and brain-penetrant small-molecule HTT pre-mRNA splicing modulator with mHTT protein EC50 of 66 nM. |
| PC-21086 |
Pladienolide B
SF3B1 inhibitor
|
Pladienolide B is a potent inhibitor targeting the SF3B1 subunit of the spliceosome, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. |
| PC-21062 |
SMNDC1 inhibitor 28
SMNDC1 inhibitor
|
SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN. |
| PC-20015 |
Rebecsinib
ADAR1p150 antagonist
|
Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation. |
| PC-73161 |
Thailanstatin D
ADC cytotoxin
|
Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities. |
