| Cat. No. |
Product Name |
Information |
| PC-38057 |
Thailanstatin C
Splicing inhibitor
|
Thailanstatin C (TST-C) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent.. |
| PC-38056 |
Thailanstatin A
Splicing inhibitor
|
Thailanstatin A (TST-A) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent.. |
| PC-38037 |
FR901465
Splicing modulator
|
FR901465 is an antitumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663, a splicing modulator with strong anticancer activities.. |
| PC-36117 |
VPC-80051
hnRNP A1 splicing inhibitor
|
VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1. |
| PC-62862 |
Herboxidiene
SF3B inhibitor
|
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. |
| PC-62507 |
Isoginkgetin
Splicing modulator, USP8 inhibitor
|
Isoginkgetin (Iso-ginkgetin, IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations. |
| PC-62422 |
Sudemycin K
Splicing inhibitor
|
Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM. |
| PC-62421 |
Sudemycin E
Splicing inhibitor
|
Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing. |
| PC-62420 |
FR901464
Spliceosome inhibitor
|
FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases. |
| PC-62419 |
Meayamycin
Spliceosome inhibitor
|
Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells. |
| PC-60872 |
N-palmitoyl-l-leucine
Spliceosome inhibitor
|
N-palmitoyl-l-leucine is a natural poduct that functions as a splicing inhibitor with IC50 of 35 uM, blocks a late stage of spliceosome assembly. |
| PC-42098 |
Madrasin
Spliceosome inhibitor
|
A small molecule inhibitor of pre-mRNA splicing that interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex. |
