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Cat. No. Product Name Information
PC-43357

Telotristat

Tryptophan hydroxylase inhibitor

Telotristat (LP-778902) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM.
PC-43356

LX1606

Tryptophan hydroxylase inhibitor

LX1606 (Telotristat ethyl) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome..
PC-62808

KAR-5585

KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice.
PC-21320

TPT-004

Tryptophan hydroxylase inhibitor

TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively.
PC-43355

Telotristat etiprate

Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome..
PC-43351

LX-1031

LX-1031 is a potent, orally active tryptophan 5-hydroxylase (TPH) inhibitor with potency of 10-100 nM, reduces 5-HT synthesis peripherally.
PC-62807

KAR-5417

KAR-5417 is a potent, selective TPH1 (tryptophan hydroxylase-1) inhibitor with IC50 of 33 nM.

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