| Cat. No. |
Product Name |
Information |
| PC-25045 |
Darusentan
ETA receptor antagonist
|
Darusentan (Lu-135252) is a selective endothelin receptor A (ETA) receptor antagonist with binding Ki of 1.4 nM, >100-fold selective over ET-B receptor. |
| PC-25044 |
Macitentan
Endothelin receptor antagonist
|
Macitentan (ACT-064992) is a potent, selective and orally active dual ETA/ETB endothelin receptor antagonist with binding IC50 of 0.5/391 nM for ETA/ETB receptors respectively. |
| PC-25043 |
Pipersentan
ETA receptor antagonist
|
Pipersentan (Diosuxentan) is a potent, selective endothelin receptor A (ETA receptor) antagonist, inhibits binding of 125I-ET-1 toward recombinant ETA receptor with IC50 of 4.44 nM, >1000-fold selective over ETB receptor. |
| PC-24438 |
RES-701-3
ETB receptor antagonist
|
RES-701-3 is a potent, selective antagonist of endothelin type B receptor (ETB receptor) with IC50 of 31.5 nM, with no activity against ETA. RES-701-3 functions as an inverse agonist. |
| PC-23821 |
BQ-788 sodium salt
ETB receptor antagonist
|
BQ-788 sodium salt is a potent, selective endothelin-B receptor (ETB) antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, >1000-fold selective over ETA receptor. |
| PC-23820 |
BQ-788
ETB receptor antagonist
|
BQ-788 is a potent, selective endothelin-B receptor (ETB) antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, >1000-fold selective over ETA receptor. |
| PC-23819 |
IRL-2500
ETB receptor antagonist
|
IRL-2500 (IRL 2500) is a potent and selective endothelin-B receptor (ETB) antagonist, inhibits binding of [125I]-endothelin-1 (ET-1) to human ETB with IC50 of 1.3 nM, 70-fold selective over ETA receptor. |
| PC-23409 |
Clazosentan
ETA antagonist
|
Clazosentan (Ro 61-1790) is a potent, selective endothelin A (ETA) receptor antagonist, 1000-fold selectivity for the ETA over ETB receptor on functional assays. |
| PC-22810 |
BQ3020 ammonium
ETB receptor agonist
|
BQ3020 ammonium is a potent, selective endothelin receptor (ETB receptor) agonist, inhibits [125I] ET-1 binding to ETB receptor with IC50 of 0.2 nM. |
