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Cat. No. Product Name Information
PC-25045

Darusentan

ETA receptor antagonist

Darusentan (Lu-135252) is a selective endothelin receptor A (ETA) receptor antagonist with binding Ki of 1.4 nM, >100-fold selective over ET-B receptor.
PC-25044

Macitentan

Endothelin receptor antagonist

Macitentan (ACT-064992) is a potent, selective and orally active dual ETA/ETB endothelin receptor antagonist with binding IC50 of 0.5/391 nM for ETA/ETB receptors respectively.
PC-25043

Pipersentan

ETA receptor antagonist

Pipersentan (Diosuxentan) is a potent, selective endothelin receptor A (ETA receptor) antagonist, inhibits binding of 125I-ET-1 toward recombinant ETA receptor with IC50 of 4.44 nM, >1000-fold selective over ETB receptor.
PC-24438

RES-701-3

ETB receptor antagonist

RES-701-3 is a potent, selective antagonist of endothelin type B receptor (ETB receptor) with IC50 of 31.5 nM, with no activity against ETA. RES-701-3 functions as an inverse agonist.
PC-23821

BQ-788 sodium salt

ETB receptor antagonist

BQ-788 sodium salt is a potent, selective endothelin-B receptor (ETB) antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, >1000-fold selective over ETA receptor.
PC-23820

BQ-788

ETB receptor antagonist

BQ-788 is a potent, selective endothelin-B receptor (ETB) antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, >1000-fold selective over ETA receptor.
PC-23819

IRL-2500

ETB receptor antagonist

IRL-2500 (IRL 2500) is a potent and selective endothelin-B receptor (ETB) antagonist, inhibits binding of [125I]-endothelin-1 (ET-1) to human ETB with IC50 of 1.3 nM, 70-fold selective over ETA receptor.
PC-23409

Clazosentan

ETA antagonist

Clazosentan (Ro 61-1790) is a potent, selective endothelin A (ETA) receptor antagonist, 1000-fold selectivity for the ETA over ETB receptor on functional assays.
PC-22810

BQ3020 ammonium

ETB receptor agonist

BQ3020 ammonium is a potent, selective endothelin receptor (ETB receptor) agonist, inhibits [125I] ET-1 binding to ETB receptor with IC50 of 0.2 nM.

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