| Cat. No. |
Product Name |
Information |
| PC-72514 |
AXKO-0046
LDHB inhibitor
|
AXKO-0046 (AXKO0046) is the first highly selective, small molecule inhibitor of human lactate dehydrogenase B (LDHB), exhibits uncompetitive LDHB inhibition with EC50 of 42 nM. |
| PC-62683 |
LDHA-IN-104
LDHA inhibitor
|
LDHA-IN-104 is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50 of 0.87 uM, less potent for LDHB (IC50=6.9 uM). |
| PC-62049 |
FX-11
LDHA inhibitor
|
FX-11 (LDHA inhibitor FX11) is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehydrogenase A (LDHA) with Ki of 50 nM (LDHA subunit M), less potent for LDHB or pLDH. |
| PC-61222 |
GSK2837808A
LDHA inhibitor
|
GSK2837808A is a potent, specific, NADH-competitive lactate dehydrogenase-A (LDHA) inhibitor with IC50 of 2.6 nM, >10-fold selectivity over LDHB. |
| PC-42245 |
GNE-140 racemate
Lactate dehydrogenase inhibitor
|
GNE-140 racemate is the racemate of GNE-140, a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively. |
| PC-42247 |
(S)-GNE-140
|
The less active enantiomer of GNE-140, inhibits LDHA activity (18-fold less potent that (R)-GNE-140). |
| PC-42246 |
(R)-GNE-140
Lactate dehydrogenase inhibitor
|
(R)-GNE-140 (GNE-140) is a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively. |
| PC-25944 |
Dual GO/LDHA inhibitor 2
GO/LDHA inhibitor
|
Dual GO/LDHA inhibitor 2 is a first-in-class, orally bioavailable dual inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) with Ki of 390 nM and 40 nM, also promotes hydrophobic tag-mediated autophagic degradation of LDHA. |
| PC-24993 |
ZG-2492
LDHA inhibitor
|
ZG-2492 is a potent, orally bioavailable inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 156 nM. |
| PC-24437 |
CHK-336
LDH inhibitor
|
CHK-336 is a potent and selective, orally active, liver-targeted inhibitor of lactate dehydrogenase (LDH) with IC50 of 0.4 nM in human enzyme assays, and IC50 of 80-131 nM in cryopreserved hepatocyte assays across species. |
| PC-23597 |
NHI-2
LDHA inhibitor
|
NHI-2 is a potent, selective inhibitor of lactate dehydrogenase A (LDHA), inhibits the aerobic glycolytic phenotype of cancer metabolism. |
| PC-23596 |
LDHA inhibitor 1g
LDHA inhibitor
|
LDHA inhibitor 1g is a potent, selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 25 nM, without affecting the LDH-B isoform (LDHB), inhibits the aerobic glycolytic phenotype of cancer metabolism. |
