| Cat. No. |
Product Name |
Information |
| PC-21218 |
HC-5404
PERK inhibitor
|
HC-5404 (LY-4) is a potent, selective and orally active inhibitor of PKR-like endoplasmic reticulum kinase (PERK, EIF2AK3) with IC50 of 1 nM. |
| PC-49644 |
PERK inhibitor 28
PERK inhibitor
|
PERK inhibitor 28 is a potent, selective, and orally bioavailable PERK inhibitor with biochemical IC50 of 2 nM, and cellular IC50 of 9 nM in p-eIF2α cellular TR-FRET assays. |
| PC-49643 |
GSK-2656157
PERK inhibitor
|
GSK2656157 (GSK 2656157) is a potent, selective and ATP-competitive inhibitor of PERK with biochemical IC50 of 0.9 nM and cellular p-PERK IC50 of 30 nM. |
| PC-49287 |
AMG PERK 44
PERK inhibitor
|
AMG PERK 44 (AMG44) is a potent, highly selective, and orally active protein kinase RNA-like ER kinase (PERK) inhibitor with IC50 of 6 nM, inhibits cellular PERK autophosphorylation (pPERK) with IC50 of 84 nM. |
| PC-38450 |
ISRIB
PERK inhibitor, eIF2α inhibitor
|
cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM. |
| PC-72030 |
PERK activator MK-28
PERK activator
|
PERK activator MK-28 is a potent, selective small molecule PERK activator with EC50 of 490 nM. |
| PC-35976 |
CCT020312
PERK activator
|
CCT020312 (CCT-020312) is a small molecule PERK activator, inhibits pRB phosphorylation in HT29 colon carcinoma cells with EC50 of 5.1 uM. |
| PC-43062 |
trans-ISRIB
PERK inhibitor
|
ISRIB trans-isomer is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM. |
| PC-45410 |
GSK2606414
PERK inhibitor
|
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM. |
| PC-20455 |
LDN‑87357
PERK inhibitor
|
LDN‑87357 is a novel small‑molecule PERK inhibitor. |
