| Cat. No. |
Product Name |
Information |
| PC-38689 |
LY3023703
mPGES-1 inhibitor
|
LY3023703 is a potent, highly selective microsomal prostaglandin E synthase 1 (mPGES1) inhibitor, dose-dependently inhibits PGE2 production in human whole blood ex vivo. |
| PC-38688 |
Zaloglanstat
mPGES-1 inhibitor
|
Zaloglanstat (ISC-27864, GRC-27864) is a potent, selective, non-opioid and orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, exhibits significant analgesic efficacy in preclinical models for osteoarthritis and inflammatory arthritis. |
| PC-38642 |
SZ0232
mPGES-2 inhibitor
|
SZ0232 is a small molecule mPGES-2 (microsomal prostaglandin E synthase-2) inhibitor with IC50 of <1 uM, exhibits beneficial effects on modulating β-cell function and glucose metabolism both in vitro and in vivo. |
| PC-38615 |
CAY10526
mPGES-1 inhibitor
|
CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression, dose-dependently inhibits PGE2 production in LPS-stimulated RAW 264.7 cells with IC50 of 1.8 uM. |
| PC-38455 |
AT-56
L-PGDS inhibitor
|
AT-56 is an orally active, selective inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with Ki of 75 uM, IC50 of 95 uM. |
| PC-36096 |
Pizuglanstat
H-PGDS inhibitor
|
TAS-205 (Pizuglanstat, TAS205) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 55.8 nM, does not inhibit LPGDS at 100 uM. |
| PC-36090 |
Crisdesalazine
mPGES-1 inhibitor
|
Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro. |
| PC-43462 |
MF63
mPGES-1 inhibitor
|
MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme, >1000-fold selectivity over other prostanoid synthases. |
| PC-43211 |
hPGDS-IN-1
H-PGDS inhibitor
|
hPGDS-IN-1 is a potent, selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor inhibitor with IC50 of 12 nM in FP or EIA assays. |
| PC-62820 |
mPGES1-IN-16
mPGES-1 inhibitor
|
mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM. |
| PC-62797 |
mPGES1-IN-17d
mPGES-1 inhibitor
|
mPGES1-IN-17d is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM, human whole blood IC50 of 249.9 nM. |
| PC-61665 |
PF-9184
mPGES-1 inhibitor
|
PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM. |
