| Cat. No. |
Product Name |
Information |
| PC-62158 |
Cyclapolin 9
PLK1 inhibitor
|
Cyclapolin 9 is a potent, selective, and ATP-competitive polo-like kinase PLK1 inhibitor with IC50 of 500 nM. |
| PC-61201 |
Poloppin II
PLK1 inhibitor
|
Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest. |
| PC-61200 |
Poloppin
PLK1 inhibitor
|
Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays. |
| PC-60180 |
Poloxin-2
PLK1 inhibitor
|
Poloxin-2 (Poloxin 2) is a potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM. |
| PC-45981 |
Poloxime
PLK1 inhibitor
|
Poloxime is an analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain (PLK1 PBD) as a phosphate mimic. |
| PC-45524 |
Centrinone B
PLK4 inhibitor
|
Centrinone B (LCR-323) is a selective, reversible PLK4 inhibitor with Ki of 0.6 nM in vitro. |
| PC-45523 |
Centrinone
PLK4 inhibitor
|
Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro. |
| PC-45884 |
GSK461364
PLK1 inhibitor
|
GSK461364 (GSK-461364) is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM. |
| PC-45847 |
BI-2536
PLK1 inhibitor
|
BI-2536 is a potent and selective inhibitor of PLK1 with IC50 of 0.83 nM. |
| PC-42779 |
GW843682X
PLK1/3 inhibitor
|
GW843682X is a potent and selective inhibitor of PLK1 (IC5=2.2 nM) and PLK3 (IC50=9 nM). |
| PC-28563 |
EXEL-1855
PLK4 inhibitor
|
EXEL-1855 is a potent, selective and orally bioavailable Polo-like kinase 4 (PLK4) inhibitor with IC50 of 7.7 nM in ADPGlo assays and EC50 of 33 nM in Nano BRET assays. |
| PC-28544 |
R1530
Mitosis/angiogenesis inhibitor, PLK4 inhibitor
|
R1530 (R-1530) is a highly potent, orally active mitosis/angiogenesis inhibitor, inhibits angiogenesis-related receptor tyrosine kinases (KDR, FGFR) with IC50 of 10 nM and 28 nM, also inhibits PLK4 with IC50 of 7.06 nM. |
