| Cat. No. |
Product Name |
Information |
| PC-27091 |
PLK3-IN-1
PLK3 inhibitor
|
PLK3-IN-1 is a potent, isoform-selective PLK3 inhibitor with IC50 of 5 nM, has 1000- and 60-fold selectivity over PLK1 and PLK2. |
| PC-25891 |
CZS-089
PLK4 inhibitor
|
CZS-089 is a potent, selective PLK4 inhibitor with IC50 of 26 nM. |
| PC-25890 |
CZS-241
PLK4 inhibitor
|
CZS-241 is a potent, selective PLK4 inhibitor with IC50 of 2.6 nM for PLK4, >1000-fold selective over TRKA. |
| PC-25889 |
CZS-034
PLK4 inhibitor
|
CZS-034 is a highly potent. selective PLK4 inhibitor with IC50 of 0.2 nM, exhibits antiproliferative activities against MCF-7, BT474, and MDA-MB-231 cells with IC50 of 0.36, 1.35, and 2.88 uM respectively. |
| PC-25888 |
CZS-035
PLK4 inhibitor
|
CZS-035 is a potent, selective PLK4 inhibitor with binding IC50 of 0.7 nM for PLK4, shows strong antiproliferative activity on MCF-7 cells with IC50 of 0.65 uM. |
| PC-25813 |
TAK-960
PLK1 inhibitor
|
TAK-960 is a potent, selective, ATP-competitive, orally available inhibitor of polo-like kinase 1 (PLK1) with IC50 of 1.6 nM in TR-FRET assays. |
| PC-24600 |
PLK1 inhibitor B4
PLK1 inhibitor
|
PLK1 inhibitor B4 is a novel small molecule inhibitor of polo-like kinase 1 (PLK1) with SPR KD of 5.6 uM, IC50 of 13.52 uM. |
| PC-24271 |
IIP0943
PLK1 inhibitor
|
IIP0943 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of 5.1 nM, exhibits high selectivity for PLK1 compared to other PLKs. |
| PC-24098 |
HMN-176
PLK1 inhibitor
|
HMN-176 is an active metabolite of HMN-214 and inhibitor of mitosis, interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly. |
| PC-24019 |
PLK1 inhibitor B31
PLK1 inhibitor
|
PLK1 inhibitor B31 is a potent, highly selective and orally active inhibitor of polo-like kinase 1 (PLK1) with IC50 of 20 nM, >200-fold selective over PLK2/PLK3. |
| PC-23368 |
TC-S 7005
PLK2 inhibitor
|
TC-S 7005 is a potent, selective polo-like kinase 2 (PLK2) inhibitor with IC50 of 4 nM, 24 nM and 214 nM for PLK2, PLK3, and PLK1, respectively. |
| PC-21170 |
SBE13
PLK1 inhibitor
|
PLK1 inhibitor SBE13 is a potent, selective PLK1 inhibitor with IC50 of 0.2 nM, with little to no inhibition against PLK2/PLK3 (IC50, 65 uM/875 nM). |
