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Cat. No. Product Name Information
PC-21636

Ningetinib

MET/AXL inhibitor

Ningetinib (CT053PTSA) is a potent, orally bioavailable multikinase inhibitor against c-Met, VEGFR2 as well as Axl, Mer, and FLT3, shows IC50s of 6.7, 1.9 and < 1.0 nM against c-Met, VEGFR-2 and Axl in cell-based assays.
PC-20461

Tepotinib

MET inhibitor

Tepotinib (EMD1214063, MSC2156119) is a potent, specific and ATP-competitive inhibitor of MET (HGFR) with IC50 of 23 nM for MET WT autophosphorylation and 2.2-42.6 nM for M1268T, Y1248H, H1112Y, L1213V, H1112L, V1110I, V1206L, and V1238I MET-mutated variants.
PC-20333

Merestinib

c-Met inhibitor

Merestinib (LY2801653) is a potent, selective, type-II ATP competitive inhibitor of c-Met with Ki of 2 nM, inhibits c-MET wt and mutant Y1230C with IC50 of 42 and 54 nM, respectively.
PC-20053

BAY-474

c-Met inhibitor

BAY-474 (BAY474) is a potent selective inhibitor of c-MET (Tyrosine-protein Kinase Met) with IC50 of <1 nM.
PC-49518

SYN1143

c-Met/Ron inhibitor

SYN1143 (AMG-1) is a potent specific small molecule inhibitor of c-Met kinase and RON with IC50 of 4 and 9 nM, inhibits c-Met signaling and cell proliferation in vitro.
PC-49517

OSI-296

c-Met/Ron inhibitor

OSI-296 is a potent and selective inhibitor of c-MET and RON kinases with cellular IC50 of 42 and 200 nM, respectively.
PC-49516

LCRF-0004

Ron kinase inhibitor

LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor with IC50 of 50 nM (ELISA), weakly inhibits c-Met with IC50 of 150 nM and does not inhibit VEGFR2.
PC-49513

XL092

VEGFR/MET/TAM inhibitor

XL092 (XL-092) is a novel small molecule multi-receptor tyrosine kinase (RTK) inhibitor, targets MET (IC50=3.0 nM), VEGFR2 (IC50=15.0 nM), and the TAM kinases TYRO3, AXL (IC50=5.8 nM), and MER (IC50=0.6 nM).
PC-49451

D6808

c-MET inhibitor

D6808 is a highly selective and potent macrocyclic c-Met inhibitor with IC50 of 2.9 nM.
PC-49280

c-MET inhibitor 7

c-MET inhibitor

c-MET inhibitor 7 is a potent, highly selective c-MET inhibitor with IC50 of 0.90 and 0.09 μM for wild-type and D1228V c-MET, respectively.
PC-49132

Dalmelitinib

c-Met inhibitor

Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.
PC-38624

Altiratinib

MET/TIE-2/VEGFR inhibitor

Altiratinib (DCC-2701) is a potent c-MET/TIE-2/VEGFR inhibitor with IC50 of 2.7 nM (MET WT), 8.0 nM (TIE2 kinase) and 9.2 nM (VEGFR2), also potently inhibits oncogenic MET mutations in the switch region (residues 1228, 1230, and 1250) with IC50 range of 0.37-6 nM.

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