| Cat. No. |
Product Name |
Information |
| PC-60074 |
Glumetinib
c-Met inhibitor
|
Glumetinib (SCC 244) is a novel potent and highly selective inhibitor of c-Met kinase with IC50 of 0.42 nM. |
| PC-45668 |
Glesatinib hydrochloride
AXL/c-Met inhibitor
|
Glesatinib (MGCD265) hydrochloride is a tyrosine kinase inhibitor that potently and selectively inhibits c-Met and Axl kinase. |
| PC-45885 |
Crizotinib
c-Met inhibitor
|
Crizotinib (PF-02341066;PF-2341066) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of c-Met catalytic activity with Ki of 4 nM. |
| PC-45842 |
Tivantinib
c-Met inhibitor
|
Tivantinib (ARQ-197) is a potent, selective, non-ATP-competitive inhibitor of c-Met with Ki of 355 nM. |
| PC-45841 |
JNJ-38877605
MET inhibitor
|
JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM. |
| PC-42535 |
Foretinib
c-Met inhibitor
|
Foretinib (XL880, GSK1363089, GSK089, EXEL-2880) is a potent, multikinase inhibitor that inhibits c-Met and VEGFR, also KIT, Flt-3, PDGFRβ, and Tie-2. |
| PC-45848 |
MK-2461
c-Met inhibitor
|
MK-2461 is a potent multitargeted kinase inhibitor that preferentially inhibits c-Met with IC50 of 2.5 nM, with similar potencies for Ron and Flt1 (IC50=7 and 10 nM, respectively). |
| PC-42618 |
BMS-794833
Met/VEGFR2 inhibitor
|
BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM. |
| PC-45530 |
AMG-337
MET inhibitor
|
AMG-337 (AMG337) is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM. |
| PC-26906 |
CX1003
MET/VEGFR-2 inhibitor
|
CX1003 is a novel multitargeted receptor tyrosine kinase inhibitor targeting MET and VEGFR types 2 (VEGFR-2, KDR), also possesses inhibitory activities against several other kinases, such as Ret. |
| PC-24709 |
MET transcriptional inhibitor C3
CAS 3082125-66-1
|
MET transcriptional inhibitor C3 is a potent MET transcriptional inhibitor, efficiently binds to the G-quadruplex (G4, Kd=73.5 nM) in the MET promoter and suppresses the expression of c-Met. |
| PC-22805 |
MET inhibitor 13
MET inhibitor
|
MET inhibitor 13 is a potent, selective and mutant-active MET kinase inhibitor with IC50 of 6/6 nM for D1228N/exon Δ14 enzyme, and 90/15/5 nM for F1200I/L1995 V/Y1230H mutants respectively. |
