| Cat. No. |
Product Name |
Information |
| PC-45045 |
PNU-159682
Topo II inhibitor, ADC cytotoxin
|
PNU-159682 (PNU159682) is a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a highly potent DNA topoisomerase II inhibitor and ADCs cytotoxin. |
| PC-28472 |
DX-8951 derivative DXd
ADC payload, Topo I inhibitor
|
DX-8951 derivative DXd (DXd, Exatecan derivative for ADC) is a potent exatecan-derived topoisomerase I (Topo I) inhibitor (IC50=0.31 uM) and ADC payload. |
| PC-28466 |
Exatecan mesylate
ADC payload, Topo I inhibitor
|
Exatecan mesylate (DX-8951f) is a potent DNA topoisomerase I (Topo I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL), exerts its cytotoxic effect by trapping the TOP1-DNA cleavage complex (TOP1cc), is a cytotoxic payload for ADCs. |
| PC-28464 |
Exatecan
ADC payload, Topo I inhibitor
|
Exatecan (DX-8951) is a potent DNA topoisomerase I (Topo I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL), exerts its cytotoxic effect by trapping the TOP1-DNA cleavage complex (TOP1cc), is a cytotoxic payload for ADCs. |
| PC-26475 |
FL118
ADC payload, DDX5 inhibitor
|
FL118 is a camptothecin derivative and payload for antibody-drug conjugates (ADCs) through topoisomerase I inhibition and proteasome-mediated degradation of anti-apoptotic proteins, also is a potent DDX5 (p68) degrader. |
| PC-46001 |
MMAF-OMe
|
An antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. |
| PC-45998 |
MMAD hydrochloride
|
A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).. |
| PC-45742 |
Ansamitocin P-3
|
A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. |
