| Cat. No. |
Product Name |
Information |
| PC-21873 |
ART0380
ATR inhibitor
|
Alnodesertib (ART0380, ART-0380) is a potent, selective and ATP-competitive ATR kinase inhibitor, inhibits ATR-ATRIP complex enzyme activity with IC50 of 51.7 nM, and phospho-Chk1 IC50 of 22 nM in cell western assay. |
| PC-73375 |
M3541
ATM inhibitor
|
M3541 (M 3541) is a novel potent, selective and ATP-competitive ATM kinase inhibitor with IC50 of 0.25 nM (ATP, 10 uM). |
| PC-72900 |
M4076
ATM inhibitor
|
Lartesertib (M4076) is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM. |
| PC-72315 |
RP-3500
ATR inhibitor
|
RP-3500 (RP3500, Camonsertib) is a novel potent, selective, orally bioavailable ATR inhibitor with IC50 of 1.0 and 0.33 nM in biochemical and cell-based assays, respectively. |
| PC-72164 |
Berzosertib
ATR inhibitor
|
Berzosertib (M6620, VX-970, VE-822) is a highly potent, selective ATR inhibitor with Ki of 0.17 nM, pH2AX IC50 of 19 nM. |
| PC-72163 |
M4344
ATR inhibitor
|
M4344 (VX-803, Gartisertib) is a highly potent, selective ATR inhibitor with Ki<0.15 nM. |
| PC-35077 |
AZ32
ATM inhibitor
|
AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM. |
| PC-42876 |
KU-60019
ATM inhibitor
|
KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR. |
| PC-42831 |
KU-55933
ATM inhibitor
|
KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases. |
| PC-62548 |
GSK635416A
ATM inhibitor
|
GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM. |
| PC-61826 |
AZD1390
ATM inhibitor
|
AZD1390 (AZD-1390) is a novel potent, selective, orally available and CNS penetrant ATM inhibitor with IC50 of 0.78 nM, displays >1,000-fold selectivity over closely related (PIKKs) and distant kinases. |
| PC-70146 |
BAY-1895344 hydrochloride
ATR inhibitor
|
BAY-1895344 (Elimusertib) hydrochloride is a potent, selective, orally active ATR inhibitor with low-nanomolar potency (IC50=7 nM). |
