| Cat. No. |
Product Name |
Information |
| PC-70111 |
ATM inhibitor AZ31
ATM inhibitor
|
AZ31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM. |
| PC-70110 |
CBP-93872
G2 checkpoint inhibitor
|
CBP-93872 is a potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint, inhibits NBS1-mediated ATR activation. |
| PC-60277 |
BAY 1895344
ATR inhibitor
|
BAY 1895344 (BAY-1895344, Elimusertib) is a novel potent, highly selective ATR kinase inhibitor with IC50 of 7.0 nM. |
| PC-44042 |
VE-821
ATR inhibitor
|
VE-821 (VE821) is a potent, selective and ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM, respectively. |
| PC-42030 |
AZD-0156
ATM inhibitor
|
AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM. |
| PC-45607 |
AZD6738
ATR inhibitor
|
AZD6738 (Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM. |
| PC-42778 |
CP-466722
ATM inhibitor
|
CP-466722 is a poten and selective ATM inhibitor (IC50=0.41 uM) without effect on ATR kinase, does not inhibit PI3K, PI3K-like protein kinases or Abl kinase. |
| PC-42333 |
GJ103 sodium salt
Read-through compound
|
GJ103 sodium salt is a novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene. |
| PC-24257 |
YY2201
ATR inhibitor
|
YY2201 is a highly potent and selective ATR inhibitor with IC50 of 8 nM, >200-fold selective over mTOR. |
| PC-22829 |
AZ20
ATR inhibitor
|
AZ20 is a potent and selective ATR inhibitor, inhibits ATR immunoprecipitated from HeLa nuclear extracts with IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with IC50 of 50 nM. |
| PC-22828 |
AD1058
ATR inhibitor
|
AD1058 is a highly potent, selective, brain-penetrant ATR inhibitor with IC50 of 1.6 nM. |
| PC-22114 |
XRD-0394 hydrochloride
ATM/DNA-PK inhibitor
|
XRD-0394 hydrochloride (XRD0394) is a potent, specific, orally bioavailable dual inhibitor of DNA damage-response kinases ATM and DNA-PK with IC50 of 0.39 and 0.89 nM, respectively. |
