| Cat. No. |
Product Name |
Information |
| PC-45607 |
AZD6738
ATR inhibitor
|
AZD6738 (Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM. |
| PC-42778 |
CP-466722
ATM inhibitor
|
CP-466722 is a poten and selective ATM inhibitor (IC50=0.41 uM) without effect on ATR kinase, does not inhibit PI3K, PI3K-like protein kinases or Abl kinase. |
| PC-42333 |
GJ103 sodium salt
|
A novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene. |
| PC-22829 |
AZ20
ATR inhibitor
|
AZ20 is a potent and selective ATR inhibitor, inhibits ATR immunoprecipitated from HeLa nuclear extracts with IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with IC50 of 50 nM. |
| PC-22828 |
AD1058
ATR inhibitor
|
AD1058 is a highly potent, selective, brain-penetrant ATR inhibitor with IC50 of 1.6 nM. |
| PC-22114 |
XRD-0394 hydrochloride
ATM/DNA-PK inhibitor
|
XRD-0394 hydrochloride (XRD0394) is a potent, specific, orally bioavailable dual inhibitor of DNA damage-response kinases ATM and DNA-PK with IC50 of 0.39 and 0.89 nM, respectively. |
| PC-22113 |
XRD-0394
ATM/DNA-PK inhibitor
|
XRD-0394 (XRD0394) is a potent and specific dual inhibitor of DNA damage-response kinases ATM and DNA-PK with IC50 of 0.39 and 0.89 nM respectively. |
| PC-21873 |
ART0380
ATR inhibitor
|
ART0380 (ART-0380) is a potent, selective and ATP-competitive ATR kinase inhibitor, inhibits ATR-ATRIP complex enzyme activity with IC50 of 51.7 nM, and phospho-Chk1 IC50 of 22 nM in cell western assay. |
| PC-21858 |
Tuvusertib
ATR inhibitor
|
Tuvusertib (M1774) is a potent, selective, orally bioavailable ATR protein kinase inhibitor, shows anticancer activity against cance cell with expression the ATR inhibition sensitizing mixed lineage leukemia fusion protein. |
| PC-21522 |
CGK733
ATM/ATR inhibitor
|
CGK733 is a specific small molecule inhibitor of ATM and ATR kinases, induces cell death in prematurely senescent breast cancer cells. |
| PC-72744 |
SKLB-197
ATR inhibitor
|
SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM. |
| PC-35077 |
AZ32
|
AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM. |
