Beta-secretase (BACE) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-60507	Atabecestat BACE1 inhibitor	Atabecestat (JNJ-54861911) is a potent, selective, brain penetrable and orally bioavailable BACE1 inhibitor with IC50 of 9.8 nM in HTRF assays, inhibits BACE2 (IC50=5.6 nM) with comparable potency as for BACE1.
PC-60085	Umibecestat BACE1 inhibitor	Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.
PC-60084	Elenbecestat BACE1 inhibitor	Elenbecestat (E-2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease.
PC-60045	Lanabecestat BACE1 inhibitor	Lanabecestat (AZD-3293, LY-3314814) is a potent, orally active and brain-permeable BACE1 inhibitor with Ki of 0.4 nM.
PC-45073	Verubecestat BACE inhibitor	Verubecestat (MK-8931) is a potent, selective, structurally unique BACE inhibitor with Ki of 2.2 nM and 0.38 nM for BACE1 and BACE2, respectively.
PC-42607	LY2811376 BACE1 inhibitor	LY2811376 is potent, orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM in enzyme assays.

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