| Cat. No. |
Product Name |
Information |
| PC-43326 |
Ivacaftor benzenesulfonate
|
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
| PC-70168 |
OSSK-630513
|
A novel potent CFTR potentiator with Kd of 31.7 nM. |
| PC-70167 |
OSSK-674842
|
A novel potent CFTR potentiator that blocks hCFTR with apparent Kd of 71.3 uM. |
| PC-45770 |
KM11060
|
A potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h). |
| PC-45455 |
GlyH-101
|
A potent CFTR inhibitor with Ki of 4.3 uM. |
| PC-45456 |
IOWH-032
|
A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis. |
