| Cat. No. |
Product Name |
Information |
| PC-28370 |
Procainamide hydrochloride
DNMT inhibitor
|
Procainamide hydrochloride (Procaine amide, SP100) is a competitive DNA methyltransferase (DNMT) inhibitor, reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes, induces vacuolization in various cell types and reduces cell proliferation and migration. |
| PC-28369 |
Procainamide
DNMT inhibitor
|
Procainamide (Procaine amide, SP100) is a competitive DNA methyltransferase (DNMT) inhibitor, reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes, induces vacuolization in various cell types and reduces cell proliferation and migration. |
| PC-28368 |
Hydralazine hydrochloride
DNMT inhibitor
|
Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase (DNMT) inhibitor, shows vasodilatory, arterial smooth muscle relaxant and hypotensive activities, also shows neuroprotective and anti-inflammatory properties. |
| PC-28367 |
Hydralazine
DNMT inhibitor
|
Hydralazine is an orally active, blood-brain barrier-permeable DNA methyltransferase (DNMT) inhibitor, shows vasodilatory, arterial smooth muscle relaxant and hypotensive activities, also shows neuroprotective and anti-inflammatory properties. |
| PC-27598 |
Decitabine
DNMT inhibitor
|
Decitabine (5-Aza-2'-deoxycytidine, 5-AZA-CdR) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase (DNMT) inhibitor, incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme, induces cell G2/M arrest and cell apoptosis. |
| PC-26866 |
Nanaomycin A
DNMT3B inhibitor
|
Nanaomycin A is a quinone antibiotics and selective DNA methyltransferase DNMT3B inhibitor with IC50 of 500 nM. |
| PC-26538 |
DMI46
DNMT1 inhibitor
|
DMI46 is a potent, selective inhibitor of DNA methyltransferase 1 (DNMT1), reverses cancer-specific DNA methylation abnormalities and tumor suppressor genes (TSGs) silencing, leading to robust antileukemic effects. |
| PC-26177 |
GSK3482364
DNMT1 inhibitor
|
GSK3482364 (GSK348236428) is a selective, reversible, orally active inhibitor of DNMT1 with IC50 of 0.4 uM, >375-fold selectivity over DNMT3A/3L and DNMT3B/3L (IC50>150 uM). |
| PC-26176 |
DMT207
DNMT1 inhibitor
|
DMT207 is a potent, selective, non-nucleoside DNMT1 (DNA Methyltransferase 1) inhibitor with IC50 of 6.88 nM. |
