| Cat. No. |
Product Name |
Information |
| PC-43810 |
SGI-1027
DNMT inhibitor
|
SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B. |
| PC-27598 |
Decitabine
DNMT inhibitor
|
Decitabine (5-Aza-2'-deoxycytidine, 5-AZA-CdR) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase (DNMT) inhibitor, incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme, induces cell G2/M arrest and cell apoptosis. |
| PC-26866 |
Nanaomycin A
DNMT3B inhibitor
|
Nanaomycin A is a quinone antibiotics and selective DNA methyltransferase DNMT3B inhibitor with IC50 of 500 nM. |
| PC-26538 |
DMI46
DNMT1 inhibitor
|
DMI46 is a potent, selective inhibitor of DNA methyltransferase 1 (DNMT1), reverses cancer-specific DNA methylation abnormalities and tumor suppressor genes (TSGs) silencing, leading to robust antileukemic effects. |
| PC-26496 |
C191-0266
METTL3 inhibitor
|
C191-0266 is a small molecule inhibitor of METTL3 with KD of 7.28 uM and enzymatic IC50 of 7.84 uM. |
| PC-26177 |
GSK3482364
DNMT1 inhibitor
|
GSK3482364 (GSK348236428) is a selective, reversible, orally active inhibitor of DNMT1 with IC50 of 0.4 uM, >375-fold selectivity over DNMT3A/3L and DNMT3B/3L (IC50>150 uM). |
| PC-26176 |
DMT207
DNMT1 inhibitor
|
DMT207 is a potent, selective, non-nucleoside DNMT1 (DNA Methyltransferase 1) inhibitor with IC50 of 6.88 nM. |
