| Cat. No. |
Product Name |
Information |
| PC-43175 |
DC-517
DNMT1 inhibitor
|
DC-517 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases. |
| PC-43174 |
DC_05
DNMT1 inhibitor
|
DC_05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM, displays 3.6-fold selectivity over PRMT1 and >15-fold over DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9.. |
| PC-61160 |
AA-CW236
MGMT inhibitor
|
AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency. |
| PC-60765 |
SGI-110
DNMT inhibitor
|
SGI-110 (Guadecitabine) is a novel DNA hypomethylating dinucleotide that inhibits DNA methyltransferase (DNMT). |
| PC-43810 |
SGI-1027
DNMT inhibitor
|
SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B. |
| PC-20786 |
RG108
DNMT inhibitor
|
RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines. |
| PC-38486 |
SW155246
DNMT1 inhibitor
|
SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM). |
| PC-73376 |
GSK3735967
DNMT1 inhibitor
|
GSK3735967 is a potent, selective, non-nucleoside inhibitor of DNMT1 with IC50 of 40 nM. |
| PC-72377 |
UHRF1 PHD inhibitor MLD4
UHRF1 inhibitor
|
UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger. |
| PC-72376 |
UHRF1 PHD inhibitor MLD5
UHRF1 inhibitor
|
UHRF1 PHD inhibitor MLD5 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=7.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger. |
| PC-72251 |
2,4-lutidine
UHRF1 inhibitor
|
2,4-lutidine is a small molecule targeting the UHRF1 tandem Tudor domain (TTD) with TR-FRET (His6-TTD vs. H3K9me3) EC50E of 29.2 uM. |
| PC-72250 |
F1957-0088
UHRF1 inhibitor
|
F1957-0088 is a small molecule targeting the UHRF1 tandem Tudor domain (TTD) with TR-FRET (TTD vs. H3K9me3) EC50 of 45.1 uM. |
