| Cat. No. |
Product Name |
Information |
| PC-38561 |
ATI-2173
HBV inhibitor
|
ATI-2173 is a novel liver-targeted prodrug of clevudine, ATI-2173 is a selective inhibitor of HBV with EC50 of 1.31 nM in primary human hepatocytes with minimal to no toxicity. |
| PC-38419 |
Rencofilstat
Cyclophilin inhibitor
|
Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM. |
| PC-73427 |
Linvencorvir
HBV inhibitor
|
Linvencorvir (RG7907, RG-7907) is an anti-HBV agent, functions as a HBV capsid assembly inhibitor. |
| PC-72718 |
AB-452
PAPD5/7 inhibitor
|
AB-452 (AB452) is a potent, small molecule inhibitor of noncanonical poly(A) polymerases PAPD5 and PAPD7 (PAPD5/7), inhibits PAPD5/7 enzymatic activities, reduces HBsAg in vitro (EC50=1.4/6.8 nM). |
| PC-72677 |
AB-506
HBV core protein inhibitor
|
AB-506 is a small-molecule inhibitor targeting HBV core protein, inhibits viral replication in vitro (IC50=77 nM). |
| PC-72258 |
RG7834
HBsAg inhibitor
|
RG7834 (RG-7834, RO7020322) is a potent, specific, orally bioavailable small molecule inhibitor of HBV gene expression, reduces HBV total mRNA levels with EC50 of 5.87 nM. |
| PC-35873 |
NVR 3-778
HBV capsid inhibitor
|
NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator. |
| PC-35638 |
NTCP binder peptide WD1
HBV entry inhibitor
|
NTCP binder peptide WD1 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=15 nM), reduces HBs antigen levels in culture supernatants. |
| PC-35637 |
NTCP binder peptide WL4
HBV entry inhibitor
|
NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM. |
| PC-35254 |
GLP-26
HBV capsid inhibitor
|
GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM. |
| PC-35216 |
JNJ-632
HBV capsid inhibitor
|
JNJ-632 (JNJ632) is a novel potent HBV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. |
| PC-63406 |
HAP-12
HBV capsid inhibitor
|
HAP-12 is a small molecule HBV capsid assembly effector that inhibits HBV DNA replication with EC50 of 0.5 uM.. |
