| Cat. No. |
Product Name |
Information |
| PC-60092 |
GNE-8505
DLK inhibitor
|
GNE-8505 (GNE8505) is a potent, selective and CNS-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. |
| PC-45651 |
NQDI-1
ASK1 inhibitor
|
NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM. |
| PC-45794 |
KIN001-266
Tpl2/MAP3K8 inhibitor
|
Tpl2-IN-34 is a potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM. |
| PC-45565 |
Selonsertib
ASK1 inhibitor
|
Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with pIC50 of 8.3. |
| PC-27856 |
Tilpisertib fosmecarbil TFA
TPL2 inhibitor
|
Tilpisertib fosmecarbil TFA (GS-5290) is an intestinally cleaved prodrug of GS-4875, a potent tumor progression locus 2 (TPL2 , COT, MAP3K8) inhibitor. |
| PC-26152 |
CS17919
ASK1 inhibitor
|
CS17919 is a potent, selective Apoptosis signal‐regulating kinase 1 (ASK1) inhibitor with IC50 of 22.52 nM, shows cell protective, anti‐inflammatory, and antifibrotic effects in vitro and in vivo. |
| PC-22734 |
Tpl2/MAP3K8 inhibitor 33
Tpl2/MAP3K8 inhibitor
|
Tpl2/MAP3K8 inhibitor 33 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 4 nM. |
| PC-22733 |
Tpl2/MAP3K8 inhibitor 32
Tpl2/MAP3K8 inhibitor
|
Tpl2/MAP3K8 inhibitor 32 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 6 nM. |
| PC-22729 |
Tpl2-2
Tpl2/MAP3K8 inhibitor
|
Tpl2-2 (TPL2 Kinase Inhibitor II) is a cell-permeable naphthyridine-cyclohexyl Tpl2-1 analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 =160 nM). |
