Cat. No. |
Product Name |
Information |
PC-38626 |
IKAM-1
MAP3K1 inhibitor
|
IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM. |
PC-38374 |
Tilpisertib
Tpl2/MAP3K8 inhibitor
|
Tilpisertib (GS-4875) is a potent, highly selective TPL2 kinase (COT, MAP3K8) inhibitor with IC50 of 1.3 nM, with no significant off-target binding activity. |
PC-72890 |
GDC-0134
DLK inhibitor
|
GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12). |
PC-35427 |
GS-444217
ASK1 inhibitor
|
GS-444217 (GS444217) is a potent, selective, ATP-competitive, orally available inhibitor of ASK1 with Kd/IC50 of 4.1/2.87 nM. |
PC-35394 |
TCASK10
ASK1 inhibitor
|
TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. |
PC-43286 |
GNE-3511
DLK inhibitor
|
GNE-3511 is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of <0.5 nM, displays >100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3. |
PC-62818 |
TAOK inhibitor 63
TAOK inhibitor
|
TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively. |
PC-62730 |
TAOK inhibitor 43
TAOK inhibitor
|
TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively. |
PC-62729 |
SW-034538
TAOK2 inhibitor
|
SW-034538 is a potent TAOK2 (Thousand-And-One Kinase 2; MAP3K17) inhibitor with IC50 of 300 nM, has cross-reactivity with respect to six of the 45 kinases (Raf1, GSK3β, JNK1, IRAK4, HGK and CDK2). |
PC-62728 |
SW-083688
TAOK2 inhibitor
|
SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM. |
PC-62726 |
GSK-114
TNNI3K inhibitor
|
GSK-114 is a potent, selective TNNI3K (TNNI3 Interacting Kinase) inhibitor with IC50 of 25 nM, dispalys 40-fold over B-Raf, exceptional broad spectrum kinase selectivity (IC50>1,000 nM, 99% of kinases, 291/294). |
PC-62541 |
MEKK2 inhibitor 1s
MEKK2 inhibitor
|
MEKK2 inhibitor 1s (MEKK2-IN-1s) is a potent MEKK2 (MAP3K2) inhibitor with IC50 of 16 nM, inhibits MEKK2 and MEKK3 with similar potencies. |