| Cat. No. |
Product Name |
Information |
| PC-35427 |
GS-444217
ASK1 inhibitor
|
GS-444217 (GS444217) is a potent, selective, ATP-competitive, orally available inhibitor of ASK1 with Kd/IC50 of 4.1/2.87 nM. |
| PC-35394 |
TC ASK10
ASK1 inhibitor
|
TC ASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. |
| PC-43286 |
GNE-3511
DLK inhibitor, LZK inhibitor
|
GNE-3511 is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of <0.5 nM, displays >100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3. |
| PC-62818 |
TAOK inhibitor 63
TAOK inhibitor
|
TAOK inhibitor 63 (TAOK-IN-2) is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively. |
| PC-62730 |
TAOK inhibitor 43
TAOK inhibitor
|
TAOK inhibitor 43 (TAOK-IN-1) is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively. |
| PC-62729 |
SW-034538
TAOK2 inhibitor
|
SW-034538 is a potent TAOK2 (Thousand-And-One Kinase 2; MAP3K17) inhibitor with IC50 of 300 nM, has cross-reactivity with respect to six of the 45 kinases (Raf1, GSK3β, JNK1, IRAK4, HGK and CDK2). |
| PC-62728 |
SW083688
TAOK2 inhibitor
|
SW083688 (SW-083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM. |
| PC-62726 |
GSK-114
TNNI3K inhibitor
|
GSK-114 is a potent, selective TNNI3K (TNNI3 Interacting Kinase) inhibitor with IC50 of 25 nM, dispalys 40-fold over B-Raf, exceptional broad spectrum kinase selectivity (IC50>1,000 nM, 99% of kinases, 291/294). |
| PC-62541 |
MEKK2 inhibitor 1s
MEKK2 inhibitor
|
MEKK2 inhibitor 1s (MEKK2-IN-1s) is a potent MEKK2 (MAP3K2) inhibitor with IC50 of 16 nM, inhibits MEKK2 and MEKK3 with similar potencies. |
| PC-60165 |
MAP3K14-IN-173
NIK inhibitor
|
MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation). |
| PC-60150 |
ASK1-IN-19
ASK1 inhibitor
|
AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3. |
| PC-70030 |
Tpl2-1
Tpl2/MAP3K8 inhibitor
|
Tpl2-1 is a potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase (Cot/MAP3K8) with IC50 of 50 nM. |
