| Cat. No. |
Product Name |
Information |
| PC-27855 |
Tilpisertib fosmecarbil
TPL2 inhibitor
|
Tilpisertib fosmecarbil (GS-5290) is an intestinally cleaved prodrug of GS-4875, a potent tumor progression locus 2 (TPL2 , COT, MAP3K8) inhibitor. |
| PC-25990 |
VU6080195
TAOK activator
|
VU6080195 is a potent, pan-TAOK (The thousand and one (TAO) kinases) activator with EC50 of 270 nM, 1376 nM and 503 nM for TAOK1, TAOK2, and TAOK3. |
| PC-25989 |
VU6083859
TAOK1 inhibitor
|
VU6083859 is a potent, selective The thousand and one (TAO) kinase TAOK1 inhibitor with IC50 of 158 nM, shows 22- and >63-fold selectivity over TAOK2 and TAOK3. |
| PC-24647 |
MAP3K1 inhibitor 51-106
MAP3K1 inhibitor
|
MAP3K1 inhibitor 51-106 is a selective MAP3K1 inhibitor with IC50 of 1.8 uM in in MAP3K1 WT cells, binds to MAP3K1 and blocks IKKβ phosphorylation, resulting in the inhibition of TNF-α-induced NF-κB activation. |
| PC-23614 |
KAI-11101
DLK inhibitor
|
KAI-11101 is a potent, selective, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 0.7 nM and cellular p-JNK IC50 of 51 nM. |
| PC-20983 |
IACS-52825
DLK inhibitor
|
IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays. |
| PC-49571 |
DLK-LZK inhibitor 64
DLK/LZK inhibitor
|
DLK-LZK inhibitor 64 (example 64) is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK) inhibitor with IC50 of 2 nM and 10 nM, respectively. |
| PC-49564 |
DN-1289
DLK/LZK inhibitor
|
DN-1289 (DN1289) is a potent, selective and CNS-penetrant dual inhibitor of leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK, MAP3K13) with IC50 of 17 nM and 40 nM, respectively. |
| PC-38656 |
ASK1 inhibitor 32
ASK1 inhibitor
|
ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 inhibitor with cellular IC50 of 25 nM. |
| PC-38626 |
IKAM-1
MAP3K1 inhibitor
|
IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM. |
| PC-38374 |
Tilpisertib
Tpl2/MAP3K8 inhibitor
|
Tilpisertib (GS-4875) is a potent, highly selective TPL2 kinase (COT, MAP3K8) inhibitor with IC50 of 1.3 nM, with no significant off-target binding activity. |
| PC-72890 |
GDC-0134
DLK inhibitor
|
GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12). |
