| Cat. No. |
Product Name |
Information |
| PC-45076 |
Valbenazine
VMAT2 inhibitor
|
Valbenazine (NBI-98854) is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor with Ki of 110-190 nM. |
| PC-28025 |
Milnacipran hydrochloride
Monoamine uptake inhibitor
|
Milnacipran hydrochloride (F2207, Midalcipran) is is an antidepressant agent via selective inhibiting the uptake of monoamines, inhibits the uptake of radiolabelled serotonin and noradrenaline with IC50 of 203 and 100 nM, respectively, but not dopamine, shows no inhibition of the activity of monoamine oxidase in vitro or in vivo. |
| PC-28022 |
Amitriptyline hydrochloride
Antidepressant
|
Amitriptyline hydrochloride is a tricyclic antidepressant by blocking SERT (Ki=3.45 nM) and NET (Ki=13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft, is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities. |
| PC-27478 |
Moleroxetine
SNRI
|
Moleroxetine is a serotonin and norepinephrin reuptake inhibitor (SNRI), can potently inhibits the activity of TRPA1. |
| PC-27444 |
Dapoxetine hydrochloride
SSRI
|
Dapoxetine hydrochloride (LY-210448) is a short-acting, orally active selective serotonin reuptake inhibitor (SSRI) for the treatment of premature ejaculation. |
| PC-27193 |
B0AT1 inhibitor compound 3
B0AT1 inhibitor
|
B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively. |
| PC-27192 |
JX225
B0AT1 inhibitor
|
JX225 is a potent, high-affinity inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 0.07 uM in FLIPR assays, and 0.44 uM in radioactive L-leucine uptake assays. |
| PC-27190 |
Cinromide
B0AT1 inhibitor
|
Cinromide is an anticonvulsant agent and potent, selective neutral amino acid transporter B0AT1 (SLC6A19) inhibitor with IC50 of 0.5 uM. |
| PC-26980 |
Fluvoxamine
Serotonin reuptake inhibitor
|
Fluvoxamine is a selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor and selective sigma-1 receptor agonist, shows ntidepressant activities. |
| PC-26734 |
Sulfasalazine
SLC7A11/xCT inhibitor
|
Sulfasalazine (NSC 667219) is a disease-modifying antirheumatic drug used to treat arthritis and ankylosing spondylitis, is a SLC7A11/xc(-) cystine/glutamate antiporter (xCT) inhibitor, has anti-leukemic activity against primary AML samples. |
| PC-26223 |
Duloxetine
SNRI
|
Duloxetine (LY248686) is a potent serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, also inhibitsvoltage-dependent K+ channels (Kv channels) with IC50 of 4.95 uM for arterial Kv currents. |
| PC-25865 |
(S)-Fluoxetine hydrochloride
SSRI
|
(S)-Fluoxetine hydrochloride (LY-110140) is a selective serotonin reuptake inhibitor (SSRI) antidepressant, inhibits the uptake of serotonin by neurons. |
