| Cat. No. |
Product Name |
Information |
| PC-46649 |
Paroxetine hydrochloride
GRK2 inhibitor, SSRI
|
Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6. |
| PC-45454 |
Amitifadine hydrochloride
Monoamine reuptake inhibitor
|
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively). |
| PC-45374 |
Radafaxine hydrochloride
DAT/NET inhibitor
|
Radafaxine hydrochloride is a potent metabolite of bupropion, selectivly inhibits the reuptake of norepinephrine over dopamine, a DAT and NET transporters inhibitor, and nAChR family modulator. |
| PC-45076 |
Valbenazine
VMAT2 inhibitor
|
Valbenazine (NBI-98854) is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor with Ki of 110-190 nM. |
| PC-28319 |
Desipramine hydrochloride
Norepinephrine reuptake inhibitor
|
Desipramine hydrochloride is a tricyclic antidepressant that selectively blocks reuptake of norepinephrine from the neuronal synapse, also inhibits serotonin reuptake, also activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. |
| PC-28318 |
Desipramine
Norepinephrine reuptake inhibitor
|
Desipramine is a tricyclic antidepressant that selectively blocks reuptake of norepinephrine from the neuronal synapse, also inhibits serotonin reuptake, also activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. |
| PC-28177 |
Bupropion hydrochloride
DAT/NET inhibitor
|
Bupropion hydrochloride (Amfebutamone) is an orally active, norepinephrine-dopamine reuptake inhibitor (NDRI), blocks dopamine (DA) uptake and Methamphetamine-induced DA release with IC50s of 1.76 uM and 14.2 uM, respectively, shows antidepressant activity. |
| PC-28025 |
Milnacipran hydrochloride
Monoamine uptake inhibitor
|
Milnacipran hydrochloride (F2207, Midalcipran) is is an antidepressant agent via selective inhibiting the uptake of monoamines, inhibits the uptake of radiolabelled serotonin and noradrenaline with IC50 of 203 and 100 nM, respectively, but not dopamine, shows no inhibition of the activity of monoamine oxidase in vitro or in vivo. |
| PC-28022 |
Amitriptyline hydrochloride
Antidepressant
|
Amitriptyline hydrochloride is a tricyclic antidepressant by blocking SERT (Ki=3.45 nM) and NET (Ki=13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft, is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities. |
| PC-27478 |
Moleroxetine
SNRI
|
Moleroxetine is a serotonin and norepinephrin reuptake inhibitor (SNRI), can potently inhibits the activity of TRPA1. |
| PC-27444 |
Dapoxetine hydrochloride
SSRI
|
Dapoxetine hydrochloride (LY-210448) is a short-acting, orally active selective serotonin reuptake inhibitor (SSRI) for the treatment of premature ejaculation. |
| PC-27192 |
JX225
B0AT1 inhibitor
|
JX225 is a potent, high-affinity inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 0.07 uM in FLIPR assays, and 0.44 uM in radioactive L-leucine uptake assays. |
