| Cat. No. |
Product Name |
Information |
| PC-28024 |
Milnacipran
Monoamine uptake inhibitor
|
Milnacipran (F2207, Midalcipran) is is an antidepressant agent via selective inhibiting the uptake of monoamines, inhibits the uptake of radiolabelled serotonin and noradrenaline with IC50 of 203 and 100 nM, respectively, but not dopamine, shows no inhibition of the activity of monoamine oxidase in vitro or in vivo. |
| PC-28021 |
Amitriptyline
Antidepressant
|
Amitriptyline is a tricyclic antidepressant by blocking SERT (Ki=3.45 nM) and NET (Ki=13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft, is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities. |
| PC-27839 |
Centanafadine hydrochloride
Triple reuptake inhibitor
|
Centanafadine hydrochloride (EB-1020 hydrochloride) is a potent triple reuptake inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT) with IC50 of 6 nM, 38 nM and 83 nM respectively. |
| PC-27838 |
Centanafadine
Triple reuptake inhibitor
|
Centanafadine (EB-1020) is a potent triple reuptake inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT) with IC50 of 6 nM, 38 nM and 83 nM respectively. |
| PC-27191 |
JX98
B0AT1 inhibitor
|
JX98 is a high-affinity inhibitor of epithelial neutral amino acid transporter B0AT1 (SLC6A19). |
| PC-25027 |
JN-170
SLC6A19 inhibitor
|
JN-170 is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 97 nM against mouse SLC6A19 in the isoleucine transport assay, > 10-fold less potent against human SLC6A19 (IC50=1.25 μM). |
| PC-25026 |
JNT-517
SLC6A19 inhibitor
|
JNT-517 (Repinatrabit, JNT517) is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 47 nM against human SLC6A19 in the isoleucine transport assay. |
| PC-22086 |
JPC-141 hydrochloride
VMAT2 inhibitor
|
JPC-141 hydrochloride is a potent, selective vesicular monoamine transporter-2 (VMAT2) inhibitor, potently inhibits [3H]dopamine uptake by VMAT2 in striatal vesicles with Ki of 52 nM. |
| PC-22085 |
JPC-141
VMAT2 inhibitor
|
JPC-141 is a potent, selective vesicular monoamine transporter-2 (VMAT2) inhibitor, potently inhibits [3H]dopamine uptake by VMAT2 in striatal vesicles with Ki of 52 nM. |
| PC-21534 |
(S)-CE-123
DAT inhibitor
|
(S)-CE-123 is a specific small molecule dopamine transporter (DAT) inhibitor with EC50 of 2.76 uM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. |
| PC-21191 |
LQFM215
SLC6A7 inhibitor
|
LQFM215 (LQFM-215) is a synthetic L-proline transporter (PROT/SLC6A7) inhibitor, inhibits proline uptake in hippocampal synaptosome with IC50 of 20.4 uM, present neuroprotective potential. |
| PC-21182 |
Ansofaxine hydrochloride
Triple reuptake inhibitor
|
Toludesvenlafaxine hydrochloride (Ansofaxine, LY03005, LPM570065) is a first-in-class triple monoaminergic reuptake inhibitor (TRI), blocks the reuptake of serotonin, dopamine, and norepinephrine with IC50 of of 723, 491 and 763 nM, respectively. |
