| Cat. No. |
Product Name |
Information |
| PC-45454 |
Amitifadine hydrochloride
Monoamine reuptake inhibitor
|
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively). |
| PC-45076 |
Valbenazine
VMAT2 inhibitor
|
Valbenazine (NBI-98854) is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor with Ki of 110-190 nM. |
| PC-25027 |
JN-170
SLC6A19 inhibitor
|
JN-170 is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 97 nM against mouse SLC6A19 in the isoleucine transport assay, > 10-fold less potent against human SLC6A19 (IC50=1.25 μM). |
| PC-25026 |
JNT-517
SLC6A19 inhibitor
|
JNT-517 (Repinatrabit, JNT517) is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 47 nM against human SLC6A19 in the isoleucine transport assay. |
| PC-24696 |
RDS-04-010
DAT inhibitor
|
RDS-04-010 is a novel atypical dopamine transporter (DAT) inhibitor with Ki of 245 nM (rDAT), binds to an inward-facing conformation of DAT. |
| PC-24214 |
Tetrabenazine
VMAT2 inhibitor
|
Tetrabenazine (Ro 1-9569) is a potent, reversible inhibitor of the vesicular monoamine transporter VMAT2 with Kd of 1.34 nM, shows potential for diseases related to hyperactive movement disorders such as Huntington's disease. |
| PC-24213 |
Deutetrabenazine
VMAT2 inhibitor
|
Deutetrabenazine is an inhibitor of vesicular monoamine transporter type 2 (VMAT2), depletes presynaptic dopamine and is useful in the treatment of hyperkinetic movement disorders. |
| PC-24119 |
Nomifensine
Monoamine reuptake inhibitor
|
Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. |
| PC-24118 |
Cendifensine
Monoamine reuptake inhibitor
|
Cendifensine is a triple monoamine reuptake inhibitor. |
| PC-23760 |
Paroxetine
GRK2 inhibitor, SSRI
|
Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6. |
| PC-23147 |
Citalopram
SSRI
|
Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI), shows antidepressant and enhances serotoninergic neurotransmission. |
| PC-22974 |
MRS7232
DAT inhibitor
|
MRS7232 is an allosteric, non-competitive inhibitor of human dopamine transporter (DAT) with EC50 of 34 nM, and norepinephrine transporter (NET), also is a potent A3AR agonist with Ki of 14.5 nM. |
