| Cat. No. |
Product Name |
Information |
| PC-20907 |
SBC110736
PCSK9 inhibitor
|
SBC110736 is a small molecule inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), reduces the release of dsDNA from UVB-induced keratinocytes. |
| PC-49373 |
7030B-C5
PCSK9 inhibitor
|
7030B-C5 is an effective small-molecule PCSK9 inhibitor with IC50 of 1.61 uM (PCSK9 transcription) in HepG2 cells, with no apparent effect on cell growth and survival. |
| PC-49372 |
NYX-PCSK9i
PCSK9 inhibitor
|
NYX-PCSK9i is an orally bioavailable small-molecule inhibitor of PCSK9, inhibits PCSK9-LDLR interaction with IC50 of 323 nM in in vitro biochemical binding assays. |
| PC-72857 |
13PCSK9i
PCSK9-LDLR inhibitor
|
13PCSK9i is a highly potent PCSK9-LDLR disruptor peptide with EC50 of 2 nM, SPR Kd of 6.1 nM and 21 nM for hPCSK9 and mPCSK9. |
| PC-38279 |
PCSK9 inhibitor 9
PCSK9 inhibitor
|
PCSK9 inhibitor 9 is a small-molecule ligand with high affinity for a novel allosteric binding site on PCSK9. |
| PC-35186 |
PCSK9-IN-7l
PCSK9 inhibitor
|
PCSK9-IN-7l is a potent, small molecule PCSK9 mRNA translation inhibitor with IC50 of 1.37 uM, shows limited bone marrow toxicity (IC50=27.1 uM). |
| PC-63171 |
SBC 115076
PCSK9 modulator
|
SBC 115076 is a PCSK9 modulator that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations. |
| PC-63170 |
PCSK9 modulator 10
PCSK9 modulator
|
PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM. |
| PC-63169 |
PF-06815345
PCSK9 modulator
|
PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay. |
| PC-62464 |
O-304
AMPK activator, PCSK9 modulator
|
O-304 is a small molecule AMPK activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats. |
| PC-60376 |
R-IMPP
PCSK9 secretion inhibitor
|
R-IMPP ((R)-IMPP, PF-00932239) is a small molecule inhibitor of PCSK9 secretion (IC50=4.8 uM) that selectively binds to human 80S ribosome, but not E. coli, ribosomes. |
| PC-70150 |
PF-06446846 hydrochloride
PCSK9 inhibitor
|
PF-06446846 hydrochloride (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells. |
