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Cat. No. Product Name Information
PC-49344

PIKfyve inhibitor 17

PIKfyve inhibitor

PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).
PC-43409

YM-201636

PIKfyve inhibitor

YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibit type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
PC-61038

Vacuolin-1

PIKfyve inhibitor

Vacuolin-1 is a potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
PC-60992

AS2795440

PIKfyve inhibitor

AS2795440 is a potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM).
PC-60991

AS2677131

AS2677131 is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM).
PC-47004

PIKfyve inhibitor WX8

PIKfyve inhibitor

WX8 is a specific inhibitor of PIKfyve, induces accumulation of cytoplasmic vacuoles on osteosarcoma U2OS cells with EC50 of 10 nM.
PC-47003

HZX-02-059

PIKfyve inhibitor

HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
PC-47002

APY0201

PIKfyve inhibitor

APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor with IC50 of 5.2 nM, displays broad anti-multiple myeloma activity with EC50 at nanomolar concentrations.
PC-60412

Apilimod

A potent IL-12/IL-23 inhibitor that down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines (IC50=2 nM).

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