| Cat. No. |
Product Name |
Information |
| PC-21872 |
M77976
PDK4 inhibitor
|
M77976 is a selective inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with IC50 of 648 uM, binds to the ATP-binding pocket of PDK4. |
| PC-63500 |
PS10
PDK inhibitor
|
PS10 (PDK inhibitor PS10) is a novel potent and highly selective pyruvate dehydrogenase kinase (PDK) inhibitor with IC50 values of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. |
| PC-24276 |
JTT251
PDHK inhibitor
|
JTT251 (JTT-251) is a potent, selective inhibitor of pyruvate dehydrogenase kinase (PDK, PDHK), bind to the allosteric lipoamide-binding domain. |
| PC-24275 |
VER-246608
PDHK inhibitor
|
VER-246608 is a potent, pan-isoform ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK, PDHK) with IC50 of 35 nM, 40 nM, 84 nM, and 91 nM for PDHK1, PDHK3, PDHK2, and PDHK4, respectively. |
| PC-23745 |
Radicicol
PDK1/PDK3 inhibitor
|
Radicicol is an inhibitor of Hsp90 with IC50 value <1 μM, also inhibits pyruvate dehydrogenase kinase (PDHK, PDK) with IC50 of 230 μM (PDK1) and 400 μM (PDK3). |
| PC-23744 |
AZD7545
PDHK inhibitor
|
AZD7545 is a potent, selective inhibitor of pyruvate dehydrogenase kinase (PDHK, PDK) with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively. |
| PC-23723 |
Sodium dichloroacetate
PDK1 inhibitor
|
Sodium dichloroacetate is a small molecule inhibitor of pyruvate dehydrogenase kinase 1 (PDK1, PDHK1), decreases lactic acid in the tumor microenvironment. |
