| Cat. No. |
Product Name |
Information |
| PC-61590 |
NVP-AST487
RET inhibitor
|
NVP-AST487 (AST487) is a potent, oral bioavailable RET kinase inhibitor with IC50 of 0.88 uM, also inhibits KDR, Flt-4, Flt-3, c-Kit and c-Abl in vitro (IC50=0.1-1.2 uM). |
| PC-61589 |
BT-13
RET agonist
|
RET agonist BT13 is a novel small molecule GDNF receptor RET agonist, potently and selectively activates RET and its downstream intracellular signaling cascades in immortalized cells (EC50~20 uM). |
| PC-61163 |
Pz-1
RET/VEGFR2 inhibitor
|
Pz-1 is a potent, dual pan-RET/VEGFR2 kinase inhibitor with IC50s of <1 nM for all RET, RET V804M and VEGFR2. |
| PC-60209 |
Selpercatinib
RET inhibitor
|
Selpercatinib (LOXO-292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. |
| PC-45558 |
BBT594
RET inhibitor
|
BBT594 (NVP-BBT594) is a potent RET inhibitor that can impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. |
| PC-35951 |
BLU-667 trans form
|
BLU-667 trans form is the trans form of BLU-667, which is a highly potent, selective, next generation RET inhibitor.. |
