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Request The Product List ofSTING STING

Cat. No. Product Name Information
PC-24613

MK-2118

STING agonist

MK-2118 is a highly potent, noncyclic dinucleotide STING agonist.
PC-24587

HG381

STING agonist

HG381 is a new-generation, non-CDN STING agonist.
PC-24586

STING agonist A4

STING agonist

STING agonist A4 is a potent, specific STING agonist, effectively activates STING in both human THP1 and mouse RAW 264.7 cells with EC50 values of 0.06 and 14.15 μM, respectively.
PC-24560

STING agonist 12b

STING agonist

STING agonist 12b is a small molecule STING agonist with EC50 of 7.45 uM and 10.23 uM for human and murine STING respectively and Emax>100% for both, directly binds to carboxy-terminal domain (CTD) (IC50=1.92 uM) and stabilizes the hSTING protein.
PC-24559

STING synergist 67

STING synergist

STING synergist 67 is a selective STING synergist with EC50 of 20.5 uM, binds to carboxy-terminal domain (CTD) of STING (SPR KD=12.2 uM), amplifies cGAMP-induced pathway activation without inherent agonist properties.
PC-24094

Excavatolide B

STING inhibitor

Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM.
PC-24093

GHN105

STING inhibitor

GHN105 is a specific, orally bioavailable, covalent STING inhibitor, selectively targets the membrane-proximal Cys91 residue of STING, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 4.4 uM.
PC-24084

E7766 diammonium salt

STING agonist

E7766 diammonium salt is a macrocycle-bridged STING agonist with ITC Kd of 40 nM, exhibits broad pan-genotypic activity in all major human STING variants.
PC-23967

Astin C

STING inhibitor

Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling.
PC-23966

STING inhibitor 42

STING inhibitor

STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively.
PC-23719

DW18343

STING agonist

DW18343 is a specific, non-nucleotide stimulator of interferon genes (STING) agonist, binds to the LBD region of the STING protein, exhibits broad‐spectrum antitumor acitvity.
PC-23577

Licochalcone D

STING inhibitor

Licochalcone D (Lico D) is a lycyrrhiza inflata-derived chalcone, potent and selective STING inhibitor, covalently modifies the Cys148 residue of STING and inhibits STING oligomerization.

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