| Cat. No. |
Product Name |
Information |
| PC-72935 |
C381
Smad activator
|
C381 (SRI011381) is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities. |
| PC-43323 |
SIS3
Smad3 inhibitor
|
SIS3 (Specific Inhibitor of Smad3) is a potent, selective inhibitor of Smad3 function and TGF-β signaling, attenuates the TGF-β1-induced phosphorylation of Smad3 (IC50=3 uM) and interaction of Smad3 with Smad4. |
| PC-62436 |
Heterotaxin
TGF-β inhibitor
|
Heterotaxin is a pyridine analog that inhibits TGF-β signaling, perturbs vascular development, melanogenesis, cell migration, and adhesion, and indirectly inhibit the phosphorylation of an intracellular mediator of TGF-β signaling. |
| PC-47500 |
Disitertide
TGF-β1 inhibitor
|
Disitertide (P144) is a TGF-β1 antagonist peptide, induces apoptosis in GBM cell lines and reduces SMAD2 phosphorylation with downregulation of SKI and an upregulation of SMAD7 at both transcriptional and translational levels; active in vivo. |
| PC-42193 |
IDE1
TGF-β activator
|
IDE1 (Inducer of definitive endoderm 1) small molecule that can induce definitive endoderm from embryonic stem cells, induces the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse ESCs in vitro with EC50 of 125.5 nM. |
| PC-42107 |
SRI-011381 hydrochloride
Smad activator
|
SRI-011381 (C381) hydrochloride is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities. |
| PC-24495 |
Pirfenidone
TGF-β inhibitor
|
Pirfenidone (AMR69) is an antifibrotic agent and TGF-β inhibitor, attenuates CCL2 and CCL12 production in fibrocyte cells, shows growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. |
